Ukuhlolwa komtholampilo sekuqalile e-Democratic Republic of the Congo (DRC) ukuze kuhlolwe ukusebenza kwesidakamizwa esilwa namagciwane i-tecovirimat (esaziwa nangokuthi i-TPOXX) kubantu abadala nasezinganeni ezinemfene.Ukuhlolwa kuzohlola ukuphepha komuthi kanye nekhono lawo lokunciphisa izimpawu zemonkeypox futhi kuvimbele imiphumela emibi, kuhlanganise nokufa.Ngaphansi kokubambisana kohulumeni be-PALM, i-National Institute of Allergy and Infectious Diseases (NIAID), ingxenye yeZikhungo Zikazwelonke Zezempilo, kanye ne-National Institute for Biomedical Research (INRB) yaseDemocratic Republic of the Congo abahola ngokubambisana kulolu cwaningo..Ama-ejensi asebenzisanayo ahlanganisa i-US Centers for Disease Control and Prevention (CDC), i-Antwerp Institute of Tropical Medicine, i-International Alliance of Health Organizations (ALIMA), kanye ne-World Health Organization (WHO).
Ikhiqizwe inkampani eyenza imithi i-SIGA Technologies, Inc. (e-New York), i-TPOXX iyi-FDA egunyazwe ingxibongo.Umuthi uvimba ukusabalala kwegciwane emzimbeni, uvimbela ukukhishwa kwezinhlayiya zegciwane kumaseli omzimba.Umuthi uqondise iphrotheni etholakala kukho kokubili igciwane lengxibongo kanye negciwane lemonkeypox.
"I-Monkeypox ibangela umthwalo omkhulu wokugula nokufa phakathi kwezingane kanye nabantu abadala eDemocratic Republic of the Congo, futhi izinketho zokwelashwa ezithuthukisiwe zidingeka ngokushesha," kusho uMqondisi we-NIAID u-Anthony S. Fauci, MD.Ukusebenza kokwelashwa kwemonkeypox.Ngithanda ukubonga ozakwethu besayensi abavela e-DRC kanye nabaseCongo ngokuqhubeka nokusebenzisana kwabo ekuthuthukiseni lolu cwaningo lomtholampilo olubalulekile.”
Igciwane lemonkeypox lidale izehlakalo ezingavamile kanye nokuqubuka kwezifo kusukela ngeminyaka yawo-1970, ikakhulukazi ezindaweni zamahlathi emvula eCentral naseNtshonalanga Afrika.Kusukela ngo-May 2022, ukubheduka kwe-monkeypox emazweni amaningi kuye kwaqhubeka ezindaweni lapho lesi sifo singakatholakali khona, okuhlanganisa i-Europe ne-United States, kanti izigameko eziningi zenzeka emadodeni aya ocansini namadoda.Ukuqubuka kwalesi sifo kwenze iWorld Health Organisation kanye noMnyango Wezempilo Nezinsizakalo Zabantu wase-US ukuthi muva nje bamemezele isimo esiphuthumayo sezempilo yomphakathi.Kusukela ngoJanuwari 1, 2022 kuya ku-Okthoba 5, 2022, i-WHO yabika amacala aqinisekisiwe angama-68,900 kanye nokufa kwabantu abangama-25 emazweni, ezifundeni nasezifundeni eziyi-106.
Ngokusho kweWorld Health Organisation, lezi zigameko ezihlonzwe njengengxenye yobhubhane oluqhubekayo emhlabeni jikelele zidalwa ikakhulukazi igciwane lemonkeypox i-Clade IIb.I-Clade I ilinganiselwa ukuthi idala izifo ezinzima kakhulu nokufa okuphezulu, ikakhulukazi ezinganeni, kune-clade IIa kanye no-clade IIb, futhi iyimbangela yokutheleleka eDemocratic Republic of the Congo.Kusukela ngomhlaka-1 Januwari 2022 kuya kuSepthemba 21, 2022, i-African Centers for Disease Control and Prevention (Africa CDC) ibike izehlakalo eziyi-3,326 zemonkeypox (kuqinisekisiwe okungu-165; kusolwa abangu-3,161) nokufa kwabantu abayi-120.
Abantu bangangenwa inkawu ngokuthintana nezilwane ezinaleli gciwane njengamagundane, izinkawu ezingezona abantu, noma abantu.Igciwane lingasakazwa phakathi kwabantu ngokuthintana ngqo nezilonda esikhumbeni, uketshezi lomzimba namaconsi aphuma emoyeni, okuhlanganisa ukusondelelana nocansi, kanye nokuthintana ngokungaqondile nezingubo ezingcolile noma izingubo zokulala.Inkawu ingabangela izimpawu ezinjengomkhuhlane kanye nezilonda esikhumbeni ezibuhlungu.Izinkinga zingahlanganisa ukuphelelwa amanzi emzimbeni, ukungenwa amagciwane, inyumoniya, ukuvuvukala kobuchopho, i-sepsis, ukungenwa yizifo zamehlo, nokufa.
Ukuhlolwa kuzobandakanya abantu abadala abangafika kwabangu-450 kanye nezingane ezinokutheleleka kwemonkeypox okuqinisekisiwe elabhorethri ezinesisindo esingu-3 kg okungenani.Abesifazane abakhulelwe nabo bayafaneleka.Abahlanganyeli bamavolontiya bazokwabelwa ngokungahleliwe ukuthi baphuze amaphilisi e-tecovirimat noma e-placebo ngomlomo kabili ngosuku izinsuku eziyi-14 ngomthamo oncike esisindweni sombambi qhaza.Ucwaningo lwalungaboni kabili, ngakho ababambiqhaza nabacwaningi babengazi ukuthi ubani owayezothola i-tecovirimat noma i-placebo.
Bonke ababambiqhaza bazohlala esibhedlela okungenani izinsuku eziyi-14 lapho bezothola khona ukunakekelwa kokusekelwa.Odokotela abangabaseshi bazoqapha njalo isimo somtholampilo sabahlanganyeli kulo lonke ucwaningo futhi bazocela ababambiqhaza ukuthi banikeze amasampula egazi, ama-swabs omphimbo, nezilonda zesikhumba ukuze kuhlolwe ilabhorethri.Inhloso eyinhloko yocwaningo kwakuwukuqhathanisa isikhathi esimaphakathi sokuphulukiswa kwezilonda zesikhumba ezigulini eziphathwa nge-tecovirimat ngokumelene ne-placebo.Abacwaningi bazophinde baqoqe idatha ngenani lezinjongo zesibili, okuhlanganisa ukuqhathanisa ukuthi ababambiqhaza basheshe bahlolwa kanjani ukuthi abanalo igciwane lemonkeypox egazini labo, ubukhali obuphelele nobude besikhathi sokugula, kanye nokufa phakathi kwamaqembu.
Abahlanganyeli bakhishwe esibhedlela ngemuva kokuthi zonke izilonda zikhuphukile noma zihlutshiwe futhi bathola ukuthi abanalo igciwane lemonkeypox egazini labo izinsuku ezimbili zilandelana.Bazobhekwa okungenani izinsuku ezingama-28 futhi bazocelwa ukuthi babuye ezinsukwini ezingama-58 ukuze bayovakashelwa ngokuzithandela ukuze bathole izivivinyo ezengeziwe zomtholampilo nezaselabhorethri.Ikomidi elizimele lokuqapha idatha nokuphepha lizoqapha ukuphepha kwabahlanganyeli kuso sonke isikhathi socwaningo.
Ucwaningo beluholwa umphenyi onguthishanhloko uJean-Jacques Muyembe-Tamfum, uMqondisi Jikelele we-INRB kanye noSolwazi weMicrobiology, iFaculty of Medicine, eNyuvesi yaseKinshasa, eGombe, eKinshasa;U-Placid Mbala, MD, uMphathi Wohlelo lwe-PALM, Inhloko ye-INRB Epidemiology Division kanye ne-Pathogen Genomics Laboratory.
“Kuyangijabulisa ukuthi inkawu ayisesona isifo esinganakiwe futhi maduze nje, ngenxa yalolu cwaningo, sizokwazi ukukhombisa ukuthi kukhona indlela yokwelapha lesi sifo,” kusho uDkt. Muyembe-Tamfum.
Ukuze uthole ulwazi olwengeziwe, vakashela i-Clinicaltrials.gov futhi useshe i-ID NCT05559099.Isheduli yokuhlola izoncika enanini lokubhalisa.Isivivinyo se-TPOXX esisekelwa yi-NIAID siyaqhubeka e-United States.Ukuze uthole ulwazi mayelana nezilingo zase-US, vakashela iwebhusayithi ye-AIDS Clinical Trials Group (ACTG) futhi useshele i-TPOXX noma funda i-A5418.
I-PALM isifinyezo se-“Pamoja Tulinde Maisha”, ibinzana lesiSwahili elisho “ukusindisa izimpilo ndawonye”.I-NIAID isungule ubambiswano locwaningo lomtholampilo lwe-PALM noMnyango Wezempilo wase-DRC ukuphendula ukuqubuka kwe-Ebola yango-2018 empumalanga ye-DRC.Ukubambisana kuyaqhubeka njengohlelo locwaningo lwezokwelapha oluhlangene oluhlanganisa i-NIAID, uMnyango Wezempilo wase-DRC, i-INRB kanye nozakwethu be-INRB.Ucwaningo lokuqala lwe-PALM lwaluyisivivinyo esilawulwa ngokungahleliwe sokwelashwa okuningi kwe-Ebola virus isifo esisekela ukugunyazwa kokulawula kwe-NIAID-developed mAb114 (Ebanga) kanye ne-REGN-EB3 (Inmazeb, eyakhiwe yi-Regeneron).
I-NIAID yenza futhi isekele ucwaningo e-NIH, e-United States, nasemhlabeni wonke ukuze kuqondwe izimbangela zezifo ezithathelwanayo nezibangelwa amasosha omzimba futhi kuthuthukiswe izindlela ezingcono zokuvimbela, ukuxilonga, nokwelapha lezi zifo.Ukukhishwa kwabezindaba, izincwadi zezindaba, nezinye izinto ezihlobene ne-NIAID ziyatholakala kuwebhusayithi ye-NIAID.
Mayelana Nezikhungo Zezempilo Zikazwelonke (NIH): I-National Institutes of Health (NIH) iyisikhungo socwaningo lwezokwelapha sase-United States esinezikhungo nezikhungo ezingama-27 futhi siyingxenye yoMnyango Wezempilo Nezinsizakalo Zabantu wase-US.I-NIH iyisikhungo sombuso esiyinhloko esenza futhi sisekele ucwaningo lwezokwelapha oluyisisekelo, lwezokwelapha, nokuhumusha, ephenya izimbangela, ukwelashwa, nokwelashwa kwezifo ezivamile nezingavamile.Ukuze uthole ulwazi olwengeziwe mayelana ne-NIH nezinhlelo zayo, vakashela ku-www.nih.gov.
Isikhathi sokuthumela: Oct-14-2022
